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Cyclooxygenase-1-Selective Inhibitors Based on the  (E)-2′-Des-methyl-sulindac Sulfide Scaffold | Journal of Medicinal Chemistry
Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold | Journal of Medicinal Chemistry

Peter Tummino on LinkedIn: Congratulations to Liang Tong and the Nimbus  team on outstanding work to…
Peter Tummino on LinkedIn: Congratulations to Liang Tong and the Nimbus team on outstanding work to…

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition  of SARS-CoV-2 infection by enzalutamide | Nature Communications
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide | Nature Communications

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding  site | Science Advances
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site | Science Advances

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases:  Synthesis, Structure–Activity Relationship, and Selective Antitumor  Activity | Journal of Medicinal Chemistry
Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity | Journal of Medicinal Chemistry

Inhibition of Prekallikrein for Hereditary Angioedema | NEJM
Inhibition of Prekallikrein for Hereditary Angioedema | NEJM

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs |  Nature Communications
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs | Nature Communications

Biomedicines | Free Full-Text | SGLT2 Inhibitors in Chronic Kidney Disease:  From Mechanisms to Clinical Practice
Biomedicines | Free Full-Text | SGLT2 Inhibitors in Chronic Kidney Disease: From Mechanisms to Clinical Practice

Structural and Functional Analysis of the Allosteric Inhibition of IRE1α  with ATP-Competitive Ligands | ACS Chemical Biology
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands | ACS Chemical Biology

A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized  nanocatalytic tumor therapeutics | Science Advances
A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics | Science Advances

GW29-e1822 CCDC11 Promotes Cardiac Hypertrophy and Dysfunction in Response  to Pressure Overload | Journal of the American College of Cardiology
GW29-e1822 CCDC11 Promotes Cardiac Hypertrophy and Dysfunction in Response to Pressure Overload | Journal of the American College of Cardiology

Inhibition of interferon-gamma-stimulated melanoma progression by targeting  neuronal nitric oxide synthase (nNOS) | Scientific Reports
Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS) | Scientific Reports

PDF) Mendelian randomization study on the causal effects of tumor necrosis  factor inhibition on coronary artery disease and ischemic stroke among the  general population
PDF) Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population

PDF) Trait impulsivity and impaired prefrontal impulse inhibition function  in adolescents with Internet gaming addiction revealed by a Go/No-Go fMRI  study
PDF) Trait impulsivity and impaired prefrontal impulse inhibition function in adolescents with Internet gaming addiction revealed by a Go/No-Go fMRI study

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome  P450 3A5 | Journal of the American Chemical Society
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5 | Journal of the American Chemical Society

PDF) Identification of Key Determinants of Cerebral Malaria Development and  Inhibition Pathways
PDF) Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways

PDF) Inhibition of GSK3 phosphorylation of β-catenin via phosphorylated  PPPSPXS motifs of Wnt coreceptor LRP6
PDF) Inhibition of GSK3 phosphorylation of β-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6

Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors |  Journal of Medicinal Chemistry
Colloidal Aggregation Causes Inhibition of G Protein-Coupled Receptors | Journal of Medicinal Chemistry

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3  Inhibition and G-Quadruplex Stabilization | Journal of the American  Chemical Society
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization | Journal of the American Chemical Society

Structural basis for inhibition of the RNA-dependent RNA polymerase from  SARS-CoV-2 by remdesivir | Science
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir | Science